Cardiology

Coronary Artery Disease

[B] ECHOCARDIOGRAM

[B] ECHOCARDIOGRAM

[C] Basal inferior wall

The most common locations of LV aneurysms are the basal inferior wall and the apex

In these locations they may grow to a large size 

[B] HOCM

Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiac disorder.

[B] HOCM

Hypertrophic cardiomyopathy 

Mavacamten - Adenosine triphosphatase inhibitor of cardiac myosin

First selective, allosteric, reversible small-molecule adenosine triphosphatase inhibitor of cardiac myosin that functions by blocking the interaction between myosin and actin within cardiac muscle cells, which exerts a negative inotropic effect.

[C] 30 mm Hg

A gradient of 30 mm Hg or more is considered hemodynamically significant and is associated with death and progression to heart failure; however, a gradient of 50 mm Hg or more is regarded as a threshold for surgical and percutaneous intervention 

[D] Basal interventricular septum

[C] Atrial fibrillation

Most common arrhythmia in HCM is atrial fibrillation - present in about 25% of patients

[A]  a  wave

[D]  Decreased intensity with standing

Harsh mid-systolic ejection murmur at the left sternal border is affected as follows: 

• Diminished intensity with increased preload (squatting) or afterload (handgrip) 

• Increased intensity with a decrease in preload (Valsalva maneuver, standing) or with any reduction in afterload (vasodilator administration)